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In post-marketing elexperiencia with SOMA, cases of dependence, isolation and abuse have been reported with prolonged use. Most cases of dependence, isolation and abuse occurred in patients who had a history of addiction or who used SOMA in combination with other medications with abuse potential. However, there have been post-marketing reports of adverse effects associated with SOMA-abuse when used without other drugs with abuse potential. Withdrawal symptoms have been reported following abrupt discontinuation after prolonged use. To reduce the likelihood of SOMA dependence, withdrawal, or abuse, SOMA should be used with caution in patients predisposed to addiction, and patients taking other CNS depressants, including alcohol, and no EMS not use more than two to three weeks for the relief of acute where can I order soma cheapest Chicago musculoskeletal pain. SOMA, and its metabolites, where can I order soma cheapest Chicago meprobamate (a controlled substance), can be addictive. There have been postmarketing reports of seizures in patients who received SOMA. Most of these cases occurred in the establishment of an overdose of multiple drugs (including drug abuse, illicit where can I order soma cheapest Chicago drugs and alcohol). The long-term studies in animals have not been conducted where can I order soma cheapest Chicago to evaluate the carcinogenic potential of carisoprodol.

In published studies, carisoprodol was where can I order soma cheapest Chicago mutagenic in the in vitro test of mouse lymphoma cells in the absence of metabolizing enzymes, but was not mutagenic in the presence of metabolizing enzymes.

Carisoprodol was clastogenic in the chromosomal aberration test in vitro with cells of Chinese hamster ovary, with or without the presence of metabolizing enzymes. Other types of genotoxicity tests yielded negative results. Carisoprodol was not mutagenic in reverse mutation assay of Ames strains of S. typhimurium, with or where can I order soma cheapest Chicago without metabolizing enzymes, and was not clastogenic in a cell in vivo mouse micronucleus circulating blood. SOMA was not formally evaluated the effects on fertility. Published reproductive studies of carisoprodol in mice found no alteration in fertility although an alteration in reproductive cycles characterized by a greater time spent in estrus was observed with a dose of carisoprodol 1200 mg / kg / day . In a toxicology study of 13 weeks do not determine the fertility of the mouse testis weight and sperm motility was where can I order soma cheapest Chicago reduced at a dose of 1200 mg / kg / day. In both studies, the NOEL was 750 mg / kg / day, corresponding to approximately 2.6 times the equivalent human dose of 350 mg four times daily, based on a comparison of the body surface. The importance of these findings for human fertility is unknown. Animal studies indicate that carisoprodol crosses the placenta and causes adverse effects on fetal growthand postnatal survival.

The major metabolite of carisoprodol, meprobamate, is an approved anxiolytic. Retrospective, post-marketing studies do not show a consistent association between maternal consumption of meprobamate and an increased risk of birth defects in particular. Animal studies have not adequately evaluated the teratogenic effects of carisoprodol. There was no increased incidence of congenital malformations observed in lesDes reproduction studies in rats, rabbits and mice treated with meprobamate.

Retrospective, post-marketing studies of meprobamate during human pregnancy where can I order soma cheapest Chicago are equivocal for demonstrating an increased risk of birth defects following exposure during the first quarter. Among the studies that have shown an increased risk of malformations incompatible types. In animal studies, carisoprodol reduced fetal weights, weight gain after birth, and postnatal survival at maternal doses equivalent to 1 to 1.5 times the human dose (based on a comparison of body surface). Rats exposed to meprobamate in utero showed behavioral alterations that persist into adulthood. For children exposed in utero to meprobamate, a study found no negative effect on the development of motor or mental health of IQ scores. SOMA should be used during pregnancy only if the potential benefit justifies the risk to the fetus.